Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials

M Nivsarkar, D Thavaselvam, S Prasanna…

Index: Nivsarkar, Manisha; Thavaselvam; Prasanna; Sharma, Mamta; Kaushik Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 5 p. 1371 - 1373

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Citation Number: 36

Abstract

Malaria has been a serious disease throughout recorded history and it continues to be one of the most widely spread health hazards. 1 It is the major parasitic infection in many tropical and subtropical regions leading to more than two million deaths out of 400 million cases reported each year. 2 Plasmodium falciparum, which causes the cerebral form of malaria, is the major contributor towards the mortality. More than half of the world's population lives in areas ...