This paper reports on the preparation of 5-amino-1, 2, 4-thiadiazol-3 (2H)-one, a sulfur- containing analogue of cytosine with the—CH= CH—group between the positions 5 and 6 of the pyrimidine ring replaced by the divalent sulfur (—S—). Improved procedures for the preparation of thiobiuret, some of its methyl derivatives and 5-amino-1, 2, 4-thiadiazol-3 (2H)- one are documented. Thiobiuret and its N-methyl derivatives were obtained by addition of ...
