Australian Journal of Chemistry

Direct One-Pot Cobalt (II) Phthalocyanine Catalyzed Synthesis of N-Substituted Isoindolinones

V Kumar, U Sharma, B Singh, N Kumar

Index: Kumar, Vishal; Sharma, Upendra; Singh, Bikram; Kumar, Neeraj Australian Journal of Chemistry, 2012 , vol. 65, # 12 p. 1594 - 1598

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Citation Number: 4

Abstract

Abstract A direct one-pot synthetic approach is described wherein cobalt (ii) phthalocyanine (CoPc) catalyzed reductive amination of 2-carboxybenzaldehyde, followed by intramolecular amidation afforded N-substituted isoindolinones. The method used diphenylsilane as reducing agent in ethanol. High chemoselectivity with excellent yield was obtained in most of the studied substrates.