Studies on the Terpenoids and Related Alicyclic Compounds. XXIX. Chemical Transformations of α-Santonin into C-8 Lactonized Eudesmanolides: Telekin and …

K YAMAKAWA, K NISHITANI…

Index: Yamakawa; Nishitani; Murakami Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 10 p. 3411 - 3417

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Abstract

The chemical transformations of α-santonin (1), a C-6 lactonized eudesmanolide, into C-8 lactonized eudesmanolides, telekin (4) and pinnatifidin (5), are described. Desulfurization of the thio-ketal (8), derived from tetrahydroyomogin (7), with Raney Ni gave the 4-ene (10),