One??Pot Synthesis of Heteroaryl and Diheteroaryl Ketones through Palladium??Catalyzed 1, 2??Addition and Oxidation

M Kuriyama, N Hamaguchi, K Sakata…

Index: Kuriyama, Masami; Hamaguchi, Norihisa; Sakata, Keisuke; Onomura, Osamu European Journal of Organic Chemistry, 2013 , # 16 p. 3378 - 3385

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Abstract

Abstract A synthetic method was developed for the preparation of heteroaryl and diheteroaryl ketones from aldehydes and organoboronic acids through a palladium- catalyzed 1, 2-addition and oxidation that uses an aryl iodide as the oxidant. This one-pot process shows high tolerance for a broad range of heterocyclic substrates by using 1.0–3.0 mol-% of the catalyst that is formed from allylpalladium chloride dimer and a thioether- ...

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