HE CONDENSATION of dithio-oxamide with Taromatic aldehydes was first described by Ephraim (I). Recently, Johnson and Ketcham (2) reported on studies concerning this reaction and established the structure of the resulting parent heterocycle as thiazolo [5,4-d]thiazole, I, with substituents at the two and five positions being equivalent . ... 1 I The purpose of our investigation was to pre- pare a number of hitherto undescribed thiazolo- thiazole derivatives for biological ...