Phosphorus pentoxide in organic synthesis. XXXV: Synthesis of thiazolo [5, 4-d] pyrimidin-7-amines and purine-6-thiones from 5-acylamino-4- …

KE Andersen, M Hammad, KMH Hilmy…

Index: Andersen, Knud Erik; Hammad, Mahmoud; Hilmy, Khalid M. H.; Pedersen, Erik B. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 10 p. 708 - 711

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Abstract

Continuing our interest2 in the synthesis of N-aryl-7-thiazolo [5, 4-d] pyrimidinamines and 9- aryl-1, 9-dihydro-6H-purine-6-thiones, we now report the synthesis of a new series of such biologically interesting3* 4 compounds. Compounds of this type have hitherto usually been prepared from pyridine derivatives.“-7 In the previous paper in this series2 we described the reaction of readily available 5-acylamino-2-methyl—4-thiazolecarboxamides [1, R2= CH3) ...