Synthesis and X-ray studies of chiral allosteric modifiers of hemoglobin

AM Youssef, MK Safo, R Danso-Danquah…

Index: Youssef, Amal Mamdouh; Safo, Martin K.; Danso-Danquah, Richmond; Joshi, Gajanan S.; Kister, Jean; Marden, Michael C.; Abraham, Donald J. Journal of Medicinal Chemistry, 2002 , vol. 45, # 6 p. 1184 - 1195

Full Text: HTML

Citation Number: 21

Abstract

This study was designed to investigate the effect of chirality on the allosteric activity of a series of Hb allosteric modifiers. The chiral analogues were based on the lead compound (4), JP7,{1-[4-(((3, 5-dimethylanilino) carbonyl) methyl) phenoxy] cyclopentanecarboxylic acid} with different d-and l-amino acids conjugated to the JP7 acid moiety. The d-isomers were the most potent in vitro effectors in Hb solutions as well as with whole blood. In ...