Tetrahedron Letters

Assymetric reduction of ketones using LiAlH 4 modified with chiral 1, 2-aminodiols. txt

JD Morrison, ER Grandbois, SI Howard, GR Weisman

Index: Morrison, James D.; Grandbois, Edward R.; Howard, Sachiko I.; Weisman, Gary R. Tetrahedron Letters, 1981 , vol. 22, # 28 p. 2619 - 2622

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Citation Number: 29

Abstract

Summary: Four chiral aminodiols from ring opening of@)-propylene oxide and ethylene oxide with n-butylamine and (3 or (ga-methylbenzylamine were used to modify LiA1H4. Asymmetric reduction of acetophenone and propiophenone gave the highest percent enantiomeric excess when the modifer was made from@-oxide and (S)-amine.