A synthesis of (2 S, 5 R)-5-hydoxylysine, based on (R)-malic acid and Williams glycine template as chiral precursors, has been developed. This afforded hydroxylysine, suitably protected for direct use in peptide synthesis, in 32% yield over the 13-step sequence. Regioselective reductive opening of ap-methoxybenzylidene acetal and alkylation of the Williams glycine template were key steps in the synthetic sequence. Surprisingly, the ...
![2,4-dibromo-6-[[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]methyl]phenol Structure](https://image.chemsrc.com/caspic/017/5420-88-2.png)