Synthesis and application of imidazole derivatives. Synthesis of (1-methyl-1H-imidazol-2-yl) methanol derivatives and conversion into carbonyl compounds.

…, S HAYAKAWA, K NISHIMURA, M OKAMOTO

Index: Ohta, Shunsaku; Hayakawa, Satoshi; Nishimura, Kazuko; Okamoto, Masao Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 3 p. 1058 - 1069

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Citation Number: 15

Abstract

(1-Methyl-1H-imidazol-2-yl) methanol derivatives (4 and 7) were prepared by treating carbonyl compounds with 2-lithio-1-methyl-1H-imidazole (2) or by treating 2-acyl-1H- imidazoles (3) with organometallic reagents or sodium borohydride. The alcohols (4 and 7) were convertible into the carbonyl compounds via the corresponding quaternary salts (8 and 10). The stable (1-methyl-1 H-imidazol-2-yl) methanol system, RC (OH)-C= N-CH= CH- ...