The Journal of organic chemistry

Revisiting nucleophilic substitution reactions: microwave-assisted synthesis of azides, thiocyanates, and sulfones in an aqueous medium

Y Ju, D Kumar, RS Varma

Index: Ju, Yuhong; Kumar, Dalip; Varma, Rajender S. Journal of Organic Chemistry, 2006 , vol. 71, # 17 p. 6697 - 6700

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Citation Number: 162

Abstract

A practical, rapid, and efficient microwave (MW) promoted synthesis of various azides, thiocyanates, and sulfones is described in an aqueous medium. This general and expeditious MW-enhanced nucleophilic substitution approach uses easily accessible starting materials such as halides or tosylates in reaction with alkali azides, thiocyanates, or sulfinates in the absence of any phase-transfer catalyst, and a variety of reactive functional ...