Tetrahedron: Asymmetry

A new approach to enantioselective cyanation of imines with Et 2 AlCN

S Nakamura, N Sato, M Sugimoto, T Toru

Index: Nakamura, Shuichi; Sato, Naoki; Sugimoto, Masashige; Toru, Takeshi Tetrahedron Asymmetry, 2004 , vol. 15, # 9 p. 1513 - 1516

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Citation Number: 90

Abstract

An enantioselective Strecker-type reaction of imines with Et2AlCN in the presence of chiral additives has been examined. The enantioselectivity varied depending on the substituents of the imino group as well as the chiral additives used. Thus, α-aminonitriles were obtained in good yields with good enantioselectivities in the reaction of N- benzylidenebenzhydrylamine with Et2AlCN and BINOL. The reaction with excess BINOL ...