Synthesis, and pharmacological screening of novel sulfamoylphenylcarbamoylquinoxaline derivatives as anti-inflammatory, analgesic and antitumour agents

AAS Farrag, YA Ammar, AAG El-Sehemi…

Index: Farrag, Awatf Al-Said; Ammar, Yousry Ahmed; El-Sehemi, Abd Allah Ghodran; Thabet, Hamdy Khamees; Hassan, Nashwa Abd-Alim; Samy, Aziza Khalil Journal of Chemical Research, 2011 , vol. 35, # 3 p. 163 - 166

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Citation Number: 6

Abstract

Treatment of quinoxaline-2, 3-dicarboxylic acid anhydride with some sulfonamides gave 3- sulfamoylphenylcarbamoylquinoxaline-2-carboxylic acid derivatives. While fusing the anhydride with the same sulfonamides produced the corresponding 3- sulfamoylphenylcarbamoylquinoxalines. On refluxing 3-sulfamoylphenylcarbamoyl derivatives with acetic anhydride gave the pyrrolo [3, 4-d] quinoxaline derivatives. The ...