Safety and Efficacy of New 3, 6??diaryl??7H??[1, 2, 4] triazolo [3, 4??b][1, 3, 4] thiadiazine Analogs as Potential Phosphodiesterase??4 Inhibitors in NIH??3T3 Mouse …

…, A Yahya??Meymandi, L Firoozpour…

Index: Baeeri, Maryam; Foroumadi, Alireza; Motamedi, Maryam; Yahya-Meymandi, Azadeh; Firoozpour, Loghman; Ostad, Seyed N.; Shafiee, Abbas; Souzangarzadeh, Saeid; Abdollahi, Mohammad Chemical Biology and Drug Design, 2011 , vol. 78, # 3 p. 438 - 444

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Citation Number: 4

Abstract

A novel series of potential phosphodiesterase-4 (PDE-4) inhibitors, 6-(3-(cyclopentyloxy)-4- methoxyphenyl)-3-aryl-7H-[1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazines, were developed. Different concentrations of the synthesized compounds were tested on cultured NIH-3T3 cells to determine their safety and efficacy in NIH-3T3 mouse fibroblastic cells in comparison with rolipram, a selective PDE-4 inhibitor. The viability of cells was determined by (3-(4, 5- ...