Synthesis of 1-(aminomethyl)-1, 2, 3, 4-tetrahydroisoquinolines and their actions at adrenoceptors in vivo and in vitro

D Beaumont, RD Waigh, M Sunbhanich…

Index: Beaumont, David; Waigh, Roger D.; Sunbhanich, Methi; Nott, Michael W. Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 507 - 515

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Citation Number: 26

Abstract

An improved synthesis of l-(aminomethyl)-l, 2, 3, 4-tetrahydroisoquinolines has been developed by using aluminum hydride reduction of l-cyano-l, 2, 3, 4-tetrahydroisoquinolines. Three 1-(aminomethyl)-6, 7-dihydroxytetrahydro-iscquinolines were tested for actions at@ adrenoceptors in order to examine a proposed similarity between this series and the related phenylethanolamines. The aminomethyl,(isopropylamino) methyl, and (tert-buty1amino) ...