Mono and bis (bioreductive) alkylating agents: synthesis and antitumor activities in a B16 melanoma model

…, S Ananthan, AM Almerico, VL Verhoef…

Index: Witiak; Loper; Ananthan; Almerico; Verhoef; Filppi Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1636 - 1642

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Citation Number: 28

Abstract

Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, and Adria Laboratories, Division of Erbemont Inc., Columbus, Ohio 43216. Received July 22, 1988 ... Several potentially bis(alky1ating) bis(quinones) (3-5) and 1,4- and 1,3-bis(alkylating) monoquinones (6-13) belonging to general structure 2,2'-ethylenebis[5-[ (leaving group)methyl]-l,4-benzoquinone]