Although phenols react with dimethyl acetylenedicarboxylate (DMAD) to give a mixture of both cis- and trans-addition products, the reaction with DMAD adsorbed on alumina gives cis-addition products stereoselectively. ... Significant improvement in regioselectivity has been achieved for a variety of organic reactions by adsorption of substrates onto the surface of inorganic solids.' However, few examples of stereoselective control using substrates adsorbed on ...
