Tetrahedron letters

Cold microwave chemistry: synthesis using pre-cooled reagents

AK Bose, SN Ganguly, MS Manhas, W He, J Speck

Index: Bose, Ajay K.; Ganguly, Subhendu N.; Manhas, Maghar S.; He, William; Speck, Jeffrey Tetrahedron Letters, 2006 , vol. 47, # 19 p. 3213 - 3215

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Citation Number: 13

Abstract

A novel experimental procedure for chemical reactions has been devised that involves mixing and then freezing the reagents (organic solvent-free) to a sub-zero temperature such as− 30° C. This frozen mixture is exposed to microwave irradiation for a brief period of time. The use of pre-cooled reagents may give a single product not obtained by traditional microwave irradiation at room temperature. Interestingly, such a product may provide ...