A series of thiazolidinone derivatives were synthesized by sodium acetate assisted cyclization of 1-isobutyl-3-phenylthiourea with chloroacetic acid followed by the piperidine facilitated substitution of the resulting thiazolidinone with different substituted aldehydes. The ethene and imine double bonds adopt (Z, Z) configuration as indicated by 1H–1H COSY and 2D-NOESY 1H NMR and further confirmed by the crystal structure studies. The in vitro ...
