Practical copper (I)-catalysed amidation of aldehydes

JWW Chang, TMU Ton, S Tania, PC Taylor…

Index: Chang, Joyce Wei Wei; Ton, Thi My Uyen; Tania, Stefani; Taylor, Paul C.; Chan, Philip Wai Hong Chemical Communications, 2010 , vol. 46, # 6 p. 922 - 924

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Citation Number: 31

Abstract

Attracted by successes in C–H bond activation using metal–nitrenoid species, 4–9 we reasoned that it might be possible to develop the direct insertion of a nitrenoid into an aldehyde C–H bond. In an initial communication we demonstrated proof of principle. 4 We showed that a ruthenium(II) porphyrin catalyst chemoselectively mediated the reaction of a wide range of aldehydes with TsN IPh to give N-acylsulfonamides. The second proof of concept stage of our ...