Expanding the Scope of Alcohol Dehydrogenases towards Bulkier Substrates: Stereo??and Enantiopreference for α, α??Dihalogenated Ketones

…, V Gotor??Fernández, J Montejo??Bernardo…

Index: Kedziora, Kinga; Bisogno, Fabricio R.; Lavandera, Ivan; Gotor-Fernandez, Vicente; Montejo-Bernardo, Jose; Garcia-Granda, Santiago; Kroutil, Wolfgang; Gotor, Vicente ChemCatChem, 2014 , vol. 6, # 4 p. 1066 - 1072

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Citation Number: 4

Abstract

Abstract Alcohol dehydrogenases (ADHs) were identified as suitable enzymes for the reduction of the corresponding α, α-dihalogenated ketones, obtaining optically pure β, β- dichloro-or β, β-dibromohydrins with excellent conversions and enantiomeric excess. Among the different biocatalysts tested, ADHs from Rhodococcus ruber (ADH-A), Ralstonia sp.(RasADH), Lactobacillus brevis (LBADH), and PR2ADH proved to be the most efficient ...