Cbz-PEG2-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Indole-C2-amide-C2-NH2 is a potent linker[1].
Chitinase has partial lysozyme activity and is widely found in bacteria, fungi, animals and some plants. Chitinase belongs to the glycosyl hydrolase family. Chitinase catalyzes chito-oligosaccharide hydrolysis[1].
DosatiLink-1 is an Abelson murine leukemia (ABL) enzyme inhibitor[1].
HIV-1 protease-IN-12 (compound 35b) is a HIV-1 protease inhibitor with an IC50 of 0.51 nM. HIV-1 protease-IN-12 also inhibits drug-resistant variant[1].
Belnacasan (VX-765) is an oral prodrug of VRT-043198, a potent and selective caspase-1 inhibitor with a Ki of 0.8 nM.
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Flutazolam (MS 4101; Ro 7-6102) is a medicine acts on benzodiazepine receptors of the brain and relieves anxiety or tension.
Cbz-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Gibberellic acid-d2 is the deuterium labeled Gibberellic acid. Gibberellic acid is named after a fungus Gibberella fujikuroi. Gibberellic Acid regulates processes of plant development and growth, including seed development and germination, stem and root growth, cell division, and flowering time[1][2].
(±)-Alliin is the main active component of garlic. (±)-Alliin is a putative inhibitor of the main protease of SARS-CoV-2 (Mpro)[1].
Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 µM and 11.06 µM against arginase I and arginase II, respectively.
N(α), N-(im)-Di-Boc-L-histidine methyl ester is a histidine derivative[1].
m-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Afimetoran is a toll-like receptor antagonist, which can be used in the research of inflammatory and autoimmune diseases[1].
Cyanidin-3-O-arabinoside is a pigment isolated from flowers of Rhododendron cv. Lems Stormcloud[1].
Ladiratuzumab (hLIV22) is an anti-LIV-1/ZIP6 humanized monoclonal antibody. Ladiratuzumab, conjugated with the microtubule disrupting agent, MMAE (HY-15162) to compose SGN-LIV1A, an antibody-drug conjugate (ADC). Ladiratuzumab can be used for research of breast cancer[1][2].
Methylisothiazolinone is a synthetic biocide and preservative that can be widely used in both industrial and consumer products. Methylisothiazolinone as a preservative in cosmetic and toiletrie products[1].
12-Dipalmitoyl-sn-glycero-3-PS-d62 (sodium salt) is deuterium labeled 12-Dipalmitoyl-sn-glycero-3-PS.
Vemurafenib-d7 is deuterium labeled Vemurafenib. Vemurafenib (PLX4032) is a first-in-class, selective, potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively[1][4]. Vemurafenib induces cell autophagy[5].
Nemiralisib hydrochloride (GSK2269557) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9.
Boc-α-(diphenylmethyl)-DL-Pro-OH is a proline derivative[1].
Ar524 has higher inhibitory activity than the known transgenic inhibitor kifunensine. At the same time, ar524 inhibited low concentration (10 μ M) Spheroid formation of human malignant cells.
PF-9184 is a potent and highly selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), with an IC50 of 16.5 nM. PF-9184 inhibits IL-1β-induced PGE2 synthesis in vitro[1].
N-Acetyl-D-valine is a valine derivative[1].
Reboxetine is an orally active, potent and selective noradrenaline uptake blocker. Reboxetine can be used for antidepressant research[1].
Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
Rhodojaponin II is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1].
Zolertine hydrochloride is an α-adrenoceptor antagonist with a pKi of 6.81 in rat liver (α1B-adrenoceptors) and 6.35 in rabbit liver (α1A-adrenoceptors) membranes[1].
GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].