11R-VIVIT is a potent NFAT inhibitor. 11R-VIVIT inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). 11R-VIVIT also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. 11R-VIVIT improves symptoms in a mouse model of colitis. Exhibits immunosuppressive effects; enhances graft survival in mice.
INCB054329 Racemate is a BET protein inhibitor.
Benzyl cinnamate-d5 is the deuterium labeled Benzyl cinnamate[1]. Benzyl cinnamate, occurs in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam, is used in heavy oriental perfumes and as a fixative[2].
3-Chloro-N,N-dimethylpropan-1-amine-d6 (hydrochloride) is the deuterium labeled 3-Chloro-N,N-dimethylpropan-1-amine hydrochloride[1].
Eleutheroside C (Ethyl α-D-galactoside) is a glycoside isolated from the bulbs of Polianthes tuberosa[1].
Prulifloxacin(NM441) is an older synthetic antibiotic of the fluoroquinolone drug class.Target: AntibacterialPrulifloxacin prevents bacterial DNA replication, transcription, repair and recombination through inhibition of bacterial DNA gyrase.
(2RS)-FPMPA can be used for synthesis of antiretroviral agents against HIV-1 and HIV-2[1].
Enterocin, an antibiotic, has static activities against gram-positive and gram-negative bacteria and no activity against fungi and yeast[1].
D-a-tert-Butyl-Gly-OH is a leucine derivative[1].
Acrivastine D7 (BW825C D7) is a deuterium labeled Acrivastine. Acrivastine is a short acting histamine 1 receptor antagonist.
9-Hydroxythymol is a thymol derivative. 9-Hydroxythymol can be isolated from Eupatorium fortunei[1].
Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.
2’-Deoxy-N6-(3-methoxybenzyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Fostamatinib disodium hexahydrate (R788 disodium hexahydrate), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
Tulrampator (CX-1632) is an orally bioavailable positive allosteric modulator of AMPA receptor (AMPAR)[1]. Antidepressant[1].
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].
NSC 5416-d14 is the deuterium labeled NSC 5416[1].
Citreorosein is a natural product that can be isolated from Xanthoria parietina[1].
AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia[1].
Polypodine B is a natural ecdysone ester isolated from the bark of Dacrydium intermedium[1].
Neuropeptide FF (5-8) is a Neuropeptide FF (HY-P1248)-related peptide. Neuropeptide FF (5-8) with a sequence of Q-P-Q-R-F-NH2 and a Ki value of 20.9 nM[1].
Carboxyatractyloside dipotassium is a toxic natural product, acts as an inhibitor of ADP/ATP carrier, inhibits mitochondrial ADP/ATP transport[1].
T-peptide is a peptide derived from microtubule binding repeat of Tau protein. T-peptide self-assembles into 30-55 nm paired helical filaments (PHFs) even in the absense of inducers. T-peptide is cytotoxic in multiple cell lines including cortical neurons, cerebellar granular neurons, neuroblastoma cells, kidney fibroblasts and HEK293 cells. T-peptide co-localizes with pathological hyperphosphorylated forms of tau in vitro.
PU-H71 is a potent Hsp90 inhibitor, with an IC50 of 51 nM in MDA-MB-468 cells.
Pectinase is a mixed enzymes that hydrolyze pectic substances, it mostly presents in microorganisms and higher plants. Pectinase is involved in the metabolism of the cell wall as well as in the growth of the cell, senescence, ripening of fruits, pathogenesis and abscission process[1].
(R)-VU 6008667, an active enantiomer of VU6008667, is a orally active acetylcholine receptor subtype 5 (M5 NAM) inhibitor with IC50 values of 1.2 μM (human) and 1.6 μM (rat), respectively. (R)-VU6008667 is selective for M5 over M1-4, high CNS penetration[1].
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2].
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations[1][2].
4-Allylcatechol (4-Allylpyrocatechol, Hydroxychavicol) is an intermediate to synthetic safrole.
14-Hydroxy sprengerinin C is a steroidal compound found in Ophiopogon japonicus.