(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺

更新时间：2025-08-23 19:28:22

(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺结构式	常用名	(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺	英文名	MK-2048
	CAS号	869901-69-9	分子量	461.874
	密度	1.6±0.1 g/cm3	沸点	N/A
	分子式	C₂₁H₂₁ClFN₅O₄	熔点	N/A
	MSDS	N/A	闪点	N/A

用途

MK-2048是HIV整合酶和INR263K的抑制剂,IC50分别为2.6 nM和1.5 nM。

中文名	(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺
英文名	(6S)-2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-6,7-dihydropyrazino[5,6]pyrrolo[1,3-b]pyridazine-4-carboxamide
英文别名	更多

描述	MK-2048是HIV整合酶和INR263K的抑制剂,IC50分别为2.6 nM和1.5 nM。
相关类别	信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶信号通路 >> 抗感染 >> HIV 研究领域 >> 感染
参考文献	[1]. L. Van Wesenbeeck, E. Rondelez, M. Feyaerts, et al. Cross-Resistance Profile Determination of Two Second-Generation HIV-1 Integrase Inhibitors Using a Panel of Recombinant Viruses Derived from Raltegravir-Treated Clinical Isolates .Antimicrob. Agents Chem [2]. Muhammad Esa Seegulam, Lee Ratner. Integrase Inhibitors Effective against Human T-Cell Leukemia Virus Type 1. Antimicrob. Agents Chemother. 2011, 55 (5): 2011-2017 [3]. Tamara Bar-Magen1, Richard D. Sloan1, Daniel A. Donahue1, et al. Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor. J. Virol. 2010, 84(18): 9210-9216 [4]. Laith Q Al-Mawsawi, Rasha I Al-Safi, Nouri Neamati. Anti-infectives Clinical progress of HIV-1 integrase inhibitors. 2008, 13(2): Pages 213-225 [5]. Al-Mawsawi LQ, Al-Safi RI, Neamati N. Anti-infectives: clinical progress of HIV-1 integrase inhibitors. Expert Opin Emerg Drugs. 2008 Jun;13(2):213-25.

描述

MK-2048是HIV整合酶和INR263K的抑制剂,IC50分别为2.6 nM和1.5 nM。

相关类别

信号通路 >> 代谢酶/蛋白酶 >> 艾滋病毒整合酶

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

参考文献

[1]. L. Van Wesenbeeck, E. Rondelez, M. Feyaerts, et al. Cross-Resistance Profile Determination of Two Second-Generation HIV-1 Integrase Inhibitors Using a Panel of Recombinant Viruses Derived from Raltegravir-Treated Clinical Isolates .Antimicrob. Agents Chem

[2]. Muhammad Esa Seegulam, Lee Ratner. Integrase Inhibitors Effective against Human T-Cell Leukemia Virus Type 1. Antimicrob. Agents Chemother. 2011, 55 (5): 2011-2017

[3]. Tamara Bar-Magen1, Richard D. Sloan1, Daniel A. Donahue1, et al. Identification of Novel Mutations Responsible for Resistance to MK-2048, a Second-Generation HIV-1 Integrase Inhibitor. J. Virol. 2010, 84(18): 9210-9216

[4]. Laith Q Al-Mawsawi, Rasha I Al-Safi, Nouri Neamati. Anti-infectives Clinical progress of HIV-1 integrase inhibitors. 2008, 13(2): Pages 213-225

[5]. Al-Mawsawi LQ, Al-Safi RI, Neamati N. Anti-infectives: clinical progress of HIV-1 integrase inhibitors. Expert Opin Emerg Drugs. 2008 Jun;13(2):213-25.

密度	1.6±0.1 g/cm3
分子式	C₂₁H₂₁ClFN₅O₄
分子量	461.874
精确质量	461.126617
PSA	109.46000
LogP	1.62
外观性状	粉末
折射率	1.698
储存条件	-20℃

(6S)-2-(3-Chloro-4-fluorobenzyl)-8-ethyl-10-hydroxy-N,6-dimethyl-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide

3oyl

ZZX

3oyn

MK-2048

Pyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxamide, 2-[(3-chloro-4-fluorophenyl)methyl]-8-ethyl-1,2,6,7,8,9-hexahydro-10-hydroxy-N,6-dimethyl-1,9-dioxo-, (6S)-

cc-267

(6S)-2-[(3-氯-4-氟苯基)甲基]-8-乙基-1,2,6,7,8,9-六氢-10-羟基-N,6-二甲基-1,9-二氧代吡嗪并[1',2':1,5]吡咯并[2,3-d]哒嗪-4-甲酰胺

用途

名称

生物活性

物理化学性质

英文别名

本网页内容来自不同专业数据源，如对内容有疑义，欢迎联系service1@chemsrc.com。