TCO-OH

更新时间：2025-08-26 18:28:08

TCO-OH结构式	常用名	TCO-OH	英文名	TCO-OH
	CAS号	85081-69-2	分子量	126.19600
	密度	N/A	沸点	N/A
	分子式	C₈H₁₄O	熔点	N/A
	MSDS	中文版美版	闪点	N/A
	符号	GHS05	信号词	Danger

TCO-OH用途

TCO-OH 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

中文名	(E)-环辛-4-烯醇
英文名	4-Cycloocten-1-ol, (4E)
英文别名	更多

描述	TCO-OH 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。
相关类别	研究领域 >> 癌症信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker
靶点	Alkyl-Chain
体外研究	PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。
参考文献	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

分子式	C₈H₁₄O
分子量	126.19600
精确质量	126.10400
PSA	20.23000
LogP	1.86760
InChIKey	UCPDHOTYYDHPEN-CMLYIYFCSA-N
SMILES	OC1CCC=CCCC1
外观性状	液体
储存条件	20°C

符号	GHS05
信号词	Danger
危害声明	H318
警示性声明	P280-P305 + P351 + P338
危害码 (欧洲)	C
风险声明 (欧洲)	41-52
安全声明 (欧洲)	26-39
危险品运输编码	NONH for all modes of transport

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Bioconjug. Chem. 22 , 2263-2270, (2011)

1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa...

Tetrazine-based cycloadditions: application to pretargeted live cell imaging.

Bioconjug. Chem. 19 , 2297-2299, (2008)

Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T...

Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

J. Am. Chem. Soc. 130 , 13518-13519, (2008)

Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol...

(E)-CYCLOOCT-4-ENOL

4-Cycloocten-1-ol, (E)-

(E)-Cyclooct-4-enol