伊曲康唑

伊曲康唑结构式
伊曲康唑
常用名 伊曲康唑 英文名 Itraconazole
CAS号 84625-61-6 分子量 705.633
密度 1.4±0.1 g/cm3 沸点 850.0±75.0 °C at 760 mmHg
分子式 C35H38Cl2N8O4 熔点 166°C
MSDS伊曲康唑的MSDS|SDS|pdf下载 中文版 美版 闪点 467.9±37.1 °C
符号 GHS07
GHS07
信号词 Warning

 伊曲康唑用途


三唑环的咪唑类抗真菌药。通过阻止细胞色素P-450包括氧化酶和过氧化酶的激活,使14,α-甲基甾醇不能脱氢、不能转化为麦角甾醇,从而使真菌的生长增殖受到抑制,有强的亲脂性,可穿过生物膜,抑制膜与真菌的结合。其抗菌谱和酮康唑相似。对表浅性真菌病如阴道和口腔念珠菌病、皮肤霉菌病等有效,并可望成为深层真菌感染病如隐球菌性脑炎(艾滋病人)的高效安全的药物。用于敏感真菌所引起的外阴阴道念珠菌病,花斑糠疹及皮肤真菌病。


 伊曲康唑名称

[ 中文名 ]: 伊曲康唑
[ 英文名 ]: itraconazole
[中文别名 ]: 4-[4-[4-[4-[[cis-2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪-1-基]苯基]-2-[(1RS)-1-甲基丙基]-1,2,4-三唑-3-酮 | 依他康唑 | 斯皮仁诺 | 亚特那唑 | 4-[4-[4-[4-[[2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]-2,4-二氢-2-(1-甲基丙基)-3H-1,2,4-三唑-3-酮
[英文别名 ]: 更多

 伊曲康唑物理化学性质

[ 密度 ]: 1.4±0.1 g/cm3
[ 沸点 ]: 850.0±75.0 °C at 760 mmHg
[ 熔点 ]: 166°C
[ 分子式 ]: C35H38Cl2N8O4
[ 分子量 ]: 705.633
[ 闪点 ]: 467.9±37.1 °C
[ 精确质量 ]: 704.239319
[ PSA ]: 104.70000
[ LogP ]: 4.35
[ 外观性状 ]: 灰白色结晶固体
[ 蒸汽压 ]: 0.0±3.2 mmHg at 25°C
[ 折射率 ]: 1.678
[ 分子结构 ]:

1、 摩尔折射率:189.33

2、 摩尔体积(cm3/mol):502.0

3、 等张比容(90.2K):1372.7

4、 表面张力(dyne/cm):55.9

5、 极化率(10-24cm3):75.05

[ 更多 ]:

1.性状:从甲苯中结晶

2.熔点(ºC):166.2

3.溶解性:几乎不溶于水和稀酸溶液。

 伊曲康唑MSDS

 伊曲康唑毒性和生态

伊曲康唑毒理学数据:

急性毒性LD50(14天)小鼠,大鼠,狗(mg/kg):>320,>320,>200口服。

伊曲康唑毒性英文版

 伊曲康唑安全信息

[ 符号 ]: GHS07
GHS07
[ 信号词 ]: Warning
[ 危害声明 ]: H302-H315-H319-H335
[ 警示性声明 ]: P261-P305 + P351 + P338
[ 个人防护装备 ]: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ 危害码 (欧洲) ]: Xi:Irritant
[ 风险声明 (欧洲) ]: R36/37/38
[ 安全声明 (欧洲) ]: S22-S26-S36
[ 危险品运输编码 ]: NONH for all modes of transport
[ WGK德国 ]: 3
[ RTECS号 ]: XZ5481000
[ 海关编码 ]: 2934999090

 伊曲康唑合成线路

2-溴丁烷结构式

CAS#:78-76-2

2-溴丁烷

cis-4-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>-2,4-dihydro-3H-1,2,4-triazol-3-one结构式

CAS#:89848-41-9

cis-4-<4-<4-<4-...

~46%

伊曲康唑结构式

CAS#:84625-61-6

伊曲康唑

文献:Heeres; Backx; Van Cutsem Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 894 - 900

 伊曲康唑上下游产品

伊曲康唑上游产品  1

伊曲康唑下游产品  0

 伊曲康唑制备

从间二氯苯出发,经和酮康唑完全相似的反应可得到化合物(I)。化合物(Ⅰ)再和1-乙酰基-4-(4-羟基苯基)哌嗪缩合,接着水解脱去乙酰基,和对硝基氯苯缩合,氢化还原,氯甲酸酯酰化,然后和水合肼反应后再环合,烷基化得伊曲康唑。其中间体1-乙酰基-4-(4-羟基苯基)哌嗪可以哌嗪为原料,经下面的反应来制备。

84625-61-6 preparation

84625-61-6 preparation

 伊曲康唑海关

[ 海关编码 ]: 2934999090
[ 中文概述 ]: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[申报要素 ]: 品名, 成分含量, 用途
[ Summary ]: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 伊曲康唑文献126

更多文献
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European Confederation of Medical Mycology (ECMM) epidemiological survey on invasive infections due to Fusarium species in Europe.

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In order to better understand the epidemiology of fusariosis in Europe, a survey collecting information on the clinical characteristics of the patients infected by Fusarium as well as on the infecting...

 伊曲康唑英文别名

2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Itrizole
Candistat
3H-1,2,4-Triazol-3-one, 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-
Sporanos
2-sec-Butyl-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
2-sec-Butyl-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinyl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
2-(Butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorphenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-on
MFCD08064196
Itrac
Cladosal 100
Canditral
(±)-1-sec-Butyl-4-[p-[4-[p-[[(2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-d2-1,2,4-triazolin-5-one
4-(4-{4-[4-({[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl}oxy)phenyl]piperazin-1-yl}phenyl)-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
4-{4-[4-(4-{[(2R,4S)-2-(2,4-Dichlorphenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-on
4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2-(1-methylpropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
Itraconazole