3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺

更新时间:2024-01-09 11:28:50

3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺结构式
3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺结构式
品牌特惠专场
常用名 3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺 英文名 VU0152100
CAS号 409351-28-6 分子量 341.42700
密度 N/A 沸点 N/A
分子式 C18H19N3O2S 熔点 N/A
MSDS 中文版 美版 闪点 N/A
符号 GHS06
GHS06
信号词 Danger

 用途


VU0152100是M4 mAChR的变构增强剂,EC50为380 nM。

 名称

中文名 3-氨基-N-[(4-甲氧基苯基)甲基]-4,6-二甲基噻吩并[2,3-B]吡啶-2-甲酰胺
英文名 3-amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide
英文别名 更多

 物理化学性质

分子式 C18H19N3O2S
分子量 341.42700
精确质量 341.12000
PSA 105.48000
LogP 4.40600
储存条件 2-8℃

 安全信息

符号 GHS06
GHS06
信号词 Danger
危害声明 H301-H319
警示性声明 P301 + P310-P305 + P351 + P338
危险品运输编码 UN 2811 6.1 / PGIII

 文献3

更多文献
Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors.

J. Neurosci. Res. 93 , 1592-9, (2015)

Dopamine and acetylcholine are two principal transmitters in the striatum and are usually balanced to modulate local neural activity and to maintain striatal homeostasis. This study investigates the r...

Investigation of the presence and antinociceptive function of muscarinic acetylcholine receptors in the African naked mole-rat (Heterocephalus glaber).

J. Comp. Physiol. A. Neuroethol. Sens. Neural. Behav. Physiol. 202 , 7-15, (2016)

The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequence...

Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.

ACS Chem. Neurosci. 5(10) , 920-42, (2014)

Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neu...

 英文别名

ML108
3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide
Kinome_1269
VU0152100
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