GEM-231

• 常用名: GEM-231
• 英文名: GEM-231
• CAS号: 255810-66-3
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: N/A
• 熔点: N/A
• 闪点: N/A

GEM-231用途

GEM231是一种靶向PKA-I (cAMP依赖性蛋白激酶I型的RIα调节亚基) mRNA 的反义寡核苷酸。GEM231在体外和体内肿瘤中诱导多种癌细胞系的细胞生长停滞、凋亡和分化。

GEM-231名称

• 英文名: GEM-231

GEM-231生物活性

• 描述: GEM231是一种靶向PKA-I (cAMP依赖性蛋白激酶I型的RIα调节亚基) mRNA 的反义寡核苷酸。GEM231在体外和体内肿瘤中诱导多种癌细胞系的细胞生长停滞、凋亡和分化。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> PKA
  信号通路 >> 干细胞及 Wnt 通路 >> PKA
• 参考文献:

  [1]. Agrawal S, Kandimalla ER, Yu D, et al. GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts. Int J Oncol. 2002;21(1):65-72.

  [2]. Mani S, Goel S, Nesterova M, et al. Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I. Ann N Y Acad Sci. 2003;1002:252-262.

  [3]. Wang H, Hang J, Shi Z, et al. Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity. Int J Oncol. 2002;21(1):73-80.

GEM-231物理化学性质

暂时没有任何物化性质资料