丁酸氯倍他松结构式
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常用名 | 丁酸氯倍他松 | 英文名 | Clobetasone butyrate |
|---|---|---|---|---|
| CAS号 | 25122-57-0 | 分子量 | 478.981 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 573.3±50.0 °C at 760 mmHg | |
| 分子式 | C26H32ClFO5 | 熔点 | 179 °C | |
| MSDS | 中文版 美版 | 闪点 | 181.1±19.3 °C | |
| 符号 |
GHS08 |
信号词 | Warning |
丁酸氯倍他松用途Clobetasone butyrate 是一种糖皮质类固醇 (glucocorticoid),具有局部抗炎活性,尤其是在皮肤上。Clobetasone butyrate 可用于缓解皮质类固醇反应性症状,包括特应性皮炎和牛皮癣。 |
| 中文名 | 丁酸倍氯他松 |
|---|---|
| 英文名 | Clobetasone 17-Butyrate |
| 中文别名 | 丁酸氯倍他松 |
| 英文别名 | 更多 |
| 描述 | Clobetasone butyrate 是一种糖皮质类固醇 (glucocorticoid),具有局部抗炎活性,尤其是在皮肤上。Clobetasone butyrate 可用于缓解皮质类固醇反应性症状,包括特应性皮炎和牛皮癣。 |
|---|---|
| 相关类别 | |
| 靶点 |
IC50: glucocorticoid[1] |
| 体内研究 | 丁酸氯倍他松(在皮肤上使用；0.05%；7周)会导致皮肤表皮变薄,丁酸氯倍他松7周导致的猪表皮变薄比氟仑雷诺酮(0.05%)或氟辛诺酮丙酮胺(0.025%)要少得多,两者都会导致严重的萎缩[1]。动物模型：大白猪[1]剂量：0.5%敷皮给药：7周结果：引起中度至轻度萎缩。 |
| 参考文献 |
[2]. Michael Stewart, et al. Clobetasone butyrate for inflammatory skin conditions. |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 573.3±50.0 °C at 760 mmHg |
| 熔点 | 179 °C |
| 分子式 | C26H32ClFO5 |
| 分子量 | 478.981 |
| 闪点 | 181.1±19.3 °C |
| 精确质量 | 478.192230 |
| PSA | 77.51000 |
| LogP | 4.82 |
| 外观性状 | 固体;White to Almost white powder to crystal |
| 蒸汽压 | 0.0±1.6 mmHg at 25°C |
| 折射率 | 1.551 |
| 储存条件 | 0-10°C;避免光,加热 |
| 稳定性 | Stable. Combustible. Incompatible with strong oxidizing agents. |
| 符号 |
GHS08 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H351 |
| 警示性声明 | P281 |
| 个人防护装备 | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| 危害码 (欧洲) | Xn:Harmful |
| 风险声明 (欧洲) | R40 |
| 安全声明 (欧洲) | S22-S36 |
| 危险品运输编码 | NONH for all modes of transport |
| RTECS号 | TU4154083 |
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Topical steroids for chronic wounds displaying abnormal inflammation.
Ann. R. Coll. Surg. Engl. 95(4) , 291-6, (2013) Chronic, non-healing wounds are often characterised by an excessive, and detrimental, inflammatory response. We review our experience of using a combined topical steroid, antibiotic and antifungal pre... |
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[Herpes gestationis].
Acta Med. Port. 17(1) , 107-9, (2004) Herpes Gestationis is a serious dermatological disease, albeit rare, associated to pregnancy or to the trophoblast diseases. Contrary to what the name suggests, it is not a viral disease but an auto-i... |
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Determination of natural and synthetic glucocorticoids in effluent of sewage treatment plants using ultrahigh performance liquid chromatography-tandem mass spectrometry.
Environ. Sci. Pollut. Res. Int. 22 , 14127-35, (2015) A sensitive and comprehensive analytical method for glucocorticoids (GCs) in water samples was developed and applied to effluent of sewage treatment plants (STPs). In the present study, totally 10 nat... |
| Kindavate |
| 21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione 17-butyrate |
| (16β)-21-chloro-9-fluoro-16-methyl-3,11,20-trioxopregna-1,4-dien-17-yl butanoate |
| 21-Chloro-9-fluoro-17-hydroxy-16b-methylpregna-1,4-diene-3,11,20-trione 17-Butyrate |
| MFCD00133196 |
| (16β)-21-Chloro-9-fluoro-16-methyl-3,11,20-trioxopregna-1,4-dien-17-yl butyrate |
| EINECS 246-635-9 |
| Butanoic acid, (16β)-21-chloro-9-fluoro-16-methyl-3,11,20-trioxopregna-1,4-dien-17-yl ester |
| Clobetasone butyrate |
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