Tomopenem

• 常用名: Tomopenem
• 英文名: Tomopenem
• CAS号: 222400-20-6
• 分子量: 537.63200
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₅N₇O₆S
• 熔点: N/A
• 闪点: N/A

Tomopenem用途

托莫培南(CS-023；RO4908463；R-115685)是一种半衰期较长的肠外碳青霉烯。Tomopenem对63种参考物种表现出广泛的活性。托莫培南对293株临床分离菌的活性很强(MIC90,0.06至4μg/mL)。抗厌氧活性[1]。

Tomopenem名称

• 英文名: (4R,5S,6S)-3-[(3S,5S)-5-[(3S)-3-[[2-(diaminomethylideneamino)acetyl]amino]pyrrolidine-1-carbonyl]-1-methylpyrrolidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Tomopenem生物活性

• 描述: 托莫培南(CS-023；RO4908463；R-115685)是一种半衰期较长的肠外碳青霉烯。Tomopenem对63种参考物种表现出广泛的活性。托莫培南对293株临床分离菌的活性很强(MIC90,0.06至4μg/mL)。抗厌氧活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Kaori Tanaka, et al. In vitro activity of tomopenem (CS-023/RO4908463) against anaerobic bacteria. Antimicrob Agents Chemother. 2009 Jan;53(1):319-22.

Tomopenem物理化学性质

• 分子式: C₂₃H₃₅N₇O₆S
• 分子量: 537.63200
• 精确质量: 537.23700
• PSA: 217.69000
• InChIKey: KEDAXBWZURNCHS-GPODMPQUSA-N
• SMILES: CC(O)C1C(=O)N2C(C(=O)O)=C(SC3CC(C(=O)N4CCC(NC(=O)CN=C(N)N)C4)N(C)C3)C(C)C12

Tomopenem英文别名

• CS-023
• (-)-(4R,5S,6S)-3-[[(3S,5S)-5-[(S)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-3-yl]thio]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• (1R,5S,6S)-2-[(2S,4S)-2-[(3S)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylic acid
• (1R,5S,6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-[(2S,4S)-2-[(3S)-3-(2-guanidinoacetylamino)pyrrolidin-1-ylcarbonyl]-1-methylpyrrolidin-4-ylthio]-1-carbapen-2-em-3-carboxylic acid
• 2-carboxylic acid
• Tomopenem
• Antibiotic CS 023
• R-1558