SB-408124盐酸盐

• 常用名: SB-408124盐酸盐
• 英文名: SB-408124 Hydrochloride
• CAS号: 1431697-90-3
• 分子量: 392.830
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₉ClF₂N₄O
• 熔点: N/A
• 闪点: N/A

SB-408124盐酸盐用途

SB408124盐酸盐是非肽类OX1受体拮抗剂,在全细胞和细胞膜测试中Ki分别为57 nM和27 nM,比对OX2受体的抑制性高50倍。

SB-408124盐酸盐名称

• 中文名: SB-408124盐酸盐
• 英文名: SB-408124 Hydrochloride

SB-408124盐酸盐生物活性

• 描述: SB408124盐酸盐是非肽类OX1受体拮抗剂,在全细胞和细胞膜测试中Ki分别为57 nM和27 nM,比对OX2受体的抑制性高50倍。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 食欲素受体(OX受体)
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Langmead et al (2004) Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 141 340.

  [2]. Morairty SR, et al. Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.PLoS One. 2012;7(7):e39131. Epub 2012 Jul 2.

  [3]. Melis MR, et al. Neuroendocrine regulatory peptide-1 and neuroendocrine regulatory peptide-2 influence differentially feeding and penile erection in male rats: sites of action in the brain.Regul Pept. 2012 Aug 20;177(1-3):46-52. Epub 2012 May 2.

  [4]. Assisi L, et al. Expression and role of receptor 1 for orexins in seminiferous tubules of rat testis.Cell Tissue Res. 2012 Jun;348(3):601-7. Epub 2012 Mar 28.

  [5]. Kis GK, et al.The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats.Pflugers Arch. 2012 Apr;463(4):531-6. Epub 2012 Feb 16.

SB-408124盐酸盐物理化学性质

• 分子式: C₁₉H₁₉ClF₂N₄O
• 分子量: 392.830
• 精确质量: 392.121552
• 储存条件: 2-8℃

SB-408124盐酸盐英文别名

• Urea, N-(6,8-difluoro-2-methyl-4-quinolinyl)-N'-[4-(dimethylamino)phenyl]-, hydrochloride (1:1)
• MFCD19443231
• 1-(6,8-Difluoro-2-methyl-4-quinolinyl)-3-[4-(dimethylamino)phenyl]urea hydrochloride (1:1)
• SB-408124 (Hydrochloride)