CEP-37440

• 常用名: CEP-37440
• 英文名: CEP-37440
• CAS号: 1391712-60-9
• 分子量: 580.121
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₃₀H₃₈ClN₇O₃
• 熔点: N/A
• 闪点: N/A

CEP-37440用途

CEP-37440是新型FAK和ALK双重抑制剂,IC50分别为2.3 nM和120 nM。

CEP-37440名称

• 中文名: CEP-37440
• 英文名: cep-37440

CEP-37440生物活性

• 描述: CEP-37440是新型FAK和ALK双重抑制剂,IC50分别为2.3 nM和120 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> ALK
  信号通路 >> 蛋白酪氨酸激酶 >> FAK
  研究领域 >> 癌症
• 参考文献:

  [1]. From PCT Int. Appl. (2013), WO 2013134353 A1 20130912.

  [2]. Salem I, et al. The effects of CEP-37440, an inhibitor of focal adhesion kinase, in vitro and in vivo on inflammatory breast cancer cells. Breast Cancer Res. 2016 Mar 24;18(1):37.

CEP-37440物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₃₀H₃₈ClN₇O₃
• 分子量: 580.121
• 精确质量: 579.272461
• PSA: 114.88000
• LogP: 3.40
• 折射率: 1.648
• 储存条件: 2-8℃

CEP-37440英文别名

• 2-(5-chloro-2-{(S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-ylamino}pyrimidin-4-ylamino)-N-methylbenzamide
• 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5Hbenzo[7]annulen-2-yl]amino]pyrimidin-4-yl]amino]-N-methyl-benzamide
• 2-{[5-Chloro-2-({(6R)-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl}amino)-4-pyrimidinyl]amino}-N-methylbenzamide
• Benzamide, 2-[[5-chloro-2-[[(6R)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-
• Benzamide, 2-[[5-chloro-2-[[(6S)-6,7,8,9-tetrahydro-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-5H-benzocyclohepten-2-yl]amino]-4-pyrimidinyl]amino]-N-methyl-
• 2-[[5-chloro-2-[[(6S)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-amino]pyrimidin-4-yl]amino]-N-methylbenzamide
• 2-{[5-Chloro-2-({(6S)-6-[4-(2-hydroxyethyl)-1-piperazinyl]-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl}amino)-4-pyrimidinyl]amino}-N-methylbenzamide