Ibandronic Acid-d3 sodium salt

• 常用名: Ibandronic Acid-d3 sodium salt
• 英文名: Ibandronic Acid-d3 sodium salt
• CAS号: 1329834-28-7
• 分子量: 344.22900
• 密度: N/A
• 沸点: N/A
• 分子式: C₉H₁₉D₃NNaO₇P₂
• 熔点: N/A
• 闪点: N/A

Ibandronic Acid-d3 sodium salt用途

伊班膦酸-d3钠盐是氘标记的伊班膦酸。伊班膦酸是一种高效含氮双膦酸盐,用于治疗骨质疏松症[1][2]。

Ibandronic Acid-d3 sodium salt名称

• 英文名: sodium,hydroxy-[1-hydroxy-3-[pentyl(trideuteriomethyl)amino]-1-phosphonopropyl]phosphinate

Ibandronic Acid-d3 sodium salt生物活性

• 描述: 伊班膦酸-d3钠盐是氘标记的伊班膦酸。伊班膦酸是一种高效含氮双膦酸盐,用于治疗骨质疏松症[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Morgan, C., S. Jeremiah, and J. Wagstaff, Metronomic administration of ibandronate and its anti-angiogenic effects in vitro. Microvasc Res, 2009. 78(3): p. 453-8.

  [3]. Epplen, R., et al., Differential effects of ibandronate, docetaxel and farnesol treatment alone and in combination on the growth of prostate cancer cell lines. Acta Oncol, 2011. 50(1): p. 127-33.

  [4]. Chesnut, I.C., et al., Effects of oral ibandronate administered daily or intermittently on fracture risk in postmenopausal osteoporosis. J Bone Miner Res, 2004. 19(8): p. 1241-9.

  [5]. Bauss, F., et al., Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged rats. J Rheumatol, 2002. 29(10): p. 2200-8.

Ibandronic Acid-d3 sodium salt物理化学性质

• 分子式: C₉H₁₉D₃NNaO₇P₂
• 分子量: 344.22900
• 精确质量: 344.09600
• PSA: 160.98000
• LogP: 0.93820
• InChIKey: LXLBEOAZMZAZND-MUTAZJQDSA-M
• SMILES: CCCCCN(C)CCC(O)(P(=O)([O-])O)P(=O)(O)O.[Na+]