GLPG0492

• 常用名: GLPG0492
• 英文名: GLPG0492
• CAS号: 1215085-92-9
• 分子量: 389.328
• 密度: 1.5±0.1 g/cm3
• 沸点: 544.0±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₄F₃N₃O₃
• 熔点: N/A
• 闪点: 282.8±32.9 °C

GLPG0492用途

GLPG0492是新型雄激素受体调节剂(SARM)。

GLPG0492名称

• 中文名: GLPG0492
• 英文名: GLPG0492

GLPG0492生物活性

• 描述: GLPG0492是新型雄激素受体调节剂(SARM)。
• 相关类别:
  信号通路 >> 其他 >> 雄激素受体
  研究领域 >> 其他
• 参考文献:

  [1]. Nique F, et al. Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55(19):8236-47.

  [2]. Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24.

  [3]. Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291.

GLPG0492物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 544.0±60.0 °C at 760 mmHg
• 分子式: C₁₉H₁₄F₃N₃O₃
• 分子量: 389.328
• 闪点: 282.8±32.9 °C
• 精确质量: 389.098724
• LogP: 2.07
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.627
• 储存条件: 2-8℃

GLPG0492英文别名

• GLPG-0492
• Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-
• 4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile