<生产厂家价格>

1-氮杂坎帕罗酮

1-氮杂坎帕罗酮用途

1-Azakenpaullone (1-Akp) 是具有高度选择性的、ATP 竞争性的糖原合成酶激酶3 β (GSK-3β) 的抑制剂,其IC50 值为 18 nM。

1-氮杂坎帕罗酮名称

[ CAS 号 ]:
676596-65-9

[ 中文名 ]:
1-氮杂坎帕罗酮

[ 英文名 ]:
1-Azakenpaullone

[英文别名 ]:

azakenpaullone
1-Azakenpaullone
Kinome_3492
HMS3229B07

1-氮杂坎帕罗酮生物活性

[ 描述 ]:

1-Azakenpaullone (1-Akp) 是具有高度选择性的、ATP 竞争性的糖原合成酶激酶3 β (GSK-3β) 的抑制剂,其IC50 值为 18 nM。

[ 相关类别 ]:

信号通路 >> 干细胞及 Wnt 通路 >> GSK-3

研究领域 >> 代谢疾病

信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3

[ 靶点 ]

GSK-3β:18 nM (IC50)

CDK1/cyclin B:2 μM (IC50)

CDK5/p25:4.2 μM (IC50)

[参考文献]

[1]. Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.

1-氮杂坎帕罗酮物理化学性质

[ 密度 ]:
1.7±0.1 g/cm3

[ 沸点 ]:
648.8±50.0 °C at 760 mmHg

[ 熔点 ]:
>290ºC (dec.)

[ 分子式 ]:
C₁₅H₁₀BrN₃O

[ 分子量 ]:
328.163

[ 闪点 ]:
346.2±30.1 °C

[ 精确质量 ]:
327.000702

[ PSA ]:
57.78000

[ LogP ]:
3.19

[ 外观性状 ]:
黄褐色固体

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.740

[ 储存条件 ]:
-20°C Freezer

[ 水溶解性 ]:
DMSO: >10mg/mL

1-氮杂坎帕罗酮MSDS

详细MSDS(安全技术说明书)

1-氮杂坎帕罗酮安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

1-氮杂坎帕罗酮文献

Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: a rapid screening model for differentiation studies.

Stem Cell Res. 12(1) , 166-77, (2014)

Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency. Recently, a combination of TGFβ and Wnt acti...

WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts.

Mol. Hum. Reprod. 21 , 711-22, (2015)

WNT/β-catenin signaling has been described as a crucial regulator of embryonic stem cells and embryogenesis. However, little is known on its role during human preimplantation embryo development, besid...

GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2.

PLoS ONE 9(9) , e107914, (2014)

The upstream stimulatory factor 2 (USF2) is a regulator of important cellular processes and is supposed to have also a role during tumor development. However, the knowledge about the mechanisms that c...

更多文献