(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

用途

红土霉素是酰基辅酶a：胆固醇酰基转移酶(ACAT)的有效抑制剂,从赤霉素IFO 7188的菌丝饼中分离出来[1]。红土霉素还抑制一小部分人类癌细胞系、革兰氏阳性细菌和白色念珠菌的生长[2]。

名称

[ CAS 号 ]:
172721-98-1

[ 英文名 ]:
(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

[英文别名 ]:

生物活性

[ 描述 ]:

红土霉素是酰基辅酶a：胆固醇酰基转移酶(ACAT)的有效抑制剂,从赤霉素IFO 7188的菌丝饼中分离出来[1]。红土霉素还抑制一小部分人类癌细胞系、革兰氏阳性细菌和白色念珠菌的生长[2]。

[ 相关类别 ]:

研究领域 >> 癌症

研究领域 >> 感染

[ 靶点 ]

IC50: 6 μM (ACAT, acyl-CoA:cholesterol acyltransferase)[1]

[参考文献]

[1]. K Hasumi, et al. Lateritin, a new inhibitor of acyl-CoA:cholesterol acyltransferase produced by Gibberella lateritium IFO 7188. J Antibiot (Tokyo).1993 Dec;46(12):1782-7.

[2]. Robin K Pettit, et al. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Med. 2010 Mar;76(5):500-1.

物理化学性质

[ 分子式 ]:
C₁₅H₁₉NO₃

[ 分子量 ]:
261.31600

[ 精确质量 ]:
261.13600

[ PSA ]:
46.61000

[ LogP ]:
1.57540

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相关化合物

CAS号[172721-98-1]化源网提供[(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>电脑版：(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione

标题：【(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione】(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-1,4-perhydrooxazine-2,5-dione CAS号:172721-98-1【结构式性质活性】-化源网地址：https://www.chemsrc.com/amp/cas/172721-98-1_1254726.html