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D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2用途

CTOP 是一种多肽,可以作为 μ-opioid receptor 的拮抗剂。

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2名称

[ CAS 号 ]:
103429-31-8

[ 中文名 ]:
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2

[ 英文名 ]:
H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 trifluoroacetate salt (Disulfide bond)

[英文别名 ]:

DPHE-CYS-TYR-DTRP-ORN-THR-PEN-THR-OL
NTB
D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-amide
M.W. 1062.26 C50H67N11O11S2
D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2
CYS2,TYR3,ORN5,PEN7-AMIDE
threoninamide
D-Phe-Cys-Tyr-D-Trp-Orn-Pen-Thr-NH2

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2生物活性

[ 描述 ]:

CTOP 是一种多肽,可以作为 μ-opioid receptor 的拮抗剂。

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

研究领域 >> 神经疾病

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2物理化学性质

[ 密度 ]:
1.42g/cm3

[ 沸点 ]:
1491.2ºC at 760mmHg

[ 分子式 ]:
C₅₀H₆₇N₁₁O₁₁S₂

[ 分子量 ]:
1062.26000

[ 闪点 ]:
855.7ºC

[ 精确质量 ]:
1061.45000

[ PSA ]:
425.91000

[ LogP ]:
3.30840

[ 蒸汽压 ]:
0mmHg at 25°C

[ 折射率 ]:
1.68

[ 储存条件 ]:
-20°C，密闭，干燥

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2MSDS

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2合成路线

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2上下游产品

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2上游产品

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2下游产品

D-PHE-CYS-TYR-D-TRP-ORN-THR-PEN-THR-NH2文献

Activation of mu or delta opioid receptors in the lumbosacral spinal cord is essential for ejaculatory reflexes in male rats.

PLoS ONE 10(3) , e0121130, (2015)

Ejaculation is controlled by a spinal ejaculation generator located in the lumbosacral spinal cord, consisting in male rats of lumbar spinothalamic (LSt) cells and their inter-spinal projections to au...

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.

J. Neurosci. 35 , 9580-94, (2015)

Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des...

Synaptic upregulation and superadditive interaction of dopamine D2- and μ-opioid receptors after peripheral nerve injury.

Pain 155(12) , 2526-33, (2014)

A sound strategy for improving the clinical efficacy of opioids involves exploiting positive interactions with drugs directed at other targets in pain pathways. The current study investigated the role...

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