(R,S′)-MNF

更新时间：2024-07-17 15:06:33 采购访问：24次

常用名	(R,S′)-MNF	CAS号	1007385-99-0
价格	$需询单/100mg $需询单/250mg $需询单/1g	纯度	98.0%
备货期	3天	库存	3
产品网页	https://www.dcchemicals.com/product_show-(r,s%e2%80%b2)-mnf.html

产品详情（用途，包装等） (R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells). (R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2. (R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells. (R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling. (R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model.

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