VX-222
更新时间：2024-01-16 13:33:49
| 常用名 | VX-222 | CAS号 | 1026785-59-0 |
|---|---|---|---|
| 价格 | ￥需询单/1kg ￥需询单/1g | 纯度 | 99.0% |
| 备货期 | 需询单 | 库存 | 询单 |
| 产品详情（用途，包装等）
用途： VX-222 (VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L.IC50 Value: 0.94 μM (HCV NS5B 1a); 1.2 μM (HCV NS5B 1b)Target: HCVVX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection. VX-222 exhibits non-competitive and selective inhibition in HCV NS5B of genotype 1a and 1b, with IC50 of 0.94 and 1.2 μM, respectively. VX-222 selectively inhibits the replication of subgenomic HCV genotype 1a and 1b with an EC50 of 22.3 and 11.2 nM, respectively. [1] Similarly, a recent study shows that VX-222 inhibits the 1b/Con1 HCV subgenomic replicon, with an EC50 of 5 nM. In rats and dogs, VCH-222 displays fine pharmacokinetic pro le, including low total body clearance and excellent oral bioavailability (greater than 30%) and good ADME properties. VCH-222 is biotransformed by several enzymes (CYP1A1, 2A6, 2B6, 2C8, CYP 3A4, UGT1A3) and is predicted to be actively transported in liver and excreted mainly intact in bile or as glucuronide adducts. 物理化学性质： CAS号：1026785-59-0 常用中文名：VX-222 常用英文名：VX-222 (VCH-222, Lomibuvir) 分子式：C25H35NO4S 分子量：445.615 密度：1.2±0.1 g/cm3 沸点：640.5±55.0 °C at 760 mmHg 熔点：N/A 闪点：341.2±31.5 °C 储存条件：-20℃ |
- 上海化源生化科技有限公司
- 上海市 上海市 普陀区
- 产品名：VX-222(VCH-222,Lomibuvir)
- 价格：
- 纯度：99.0%
- 备货期：10天
- 联系人：徐经理
- 上海源溪生物科技有限公司
- 上海市 上海市 浦东新区
- 产品名：VX222(Lomibuvir)
- 价格： ￥需询单/1g
- 纯度：98.9%
- 备货期：1天
- 联系人：赖经理
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：VX-222 (VCH-222, Lomibuvir)
- 价格： ￥1066.9/1ml ￥1338.9/10mg ￥494.9/1mg ￥823.9/5mg
- 纯度：98.0%
- 备货期：1天
- 联系人：阿拉丁
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参考价格：$132/10mM*1mLinDMSO