Synthesis and antimicrobial and cytotoxic activities of pyrrole-containing analogs of trichostatin A

…, M Artico, F Corelli, A Mai, R Di Santo…

文献索引：Massa, S.; Artico, M.; Corelli, F.; Mai, A.; Santo, R. Di; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2845 - 2849

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被引用次数: 27

摘要

A number of aroylpyrroleacrylic acid derivatives were synthesized by standard procedures and evaluated for cytotoxicity in Vero cells and for capacity to inhibit the multiplication of viruses, bacteria, and fungi. While none of the test compounds showed any activity against bacteria and fungi, most of them inhibited the replication of some DNA viruses at concentrations allowing the exponential growth of uninfected cells. In particular three ...