12-脱氧佛13-苯乙酸20-醋酸
12-脱氧佛13-苯乙酸20-醋酸结构式
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常用名 | 12-脱氧佛13-苯乙酸20-醋酸 | 英文名 | 12-deoxyphorbol 13-phenylacetate 20-acetate |
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| CAS号 | 54662-30-5 | 分子量 | 508.60300 | |
| 密度 | 1.29g/cm3 | 沸点 | 635.7ºC at 760 mmHg | |
| 分子式 | C30H36O7 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 204.3ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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Phosphorylation of connexin43 and inhibition of gap junctional communication in 12-O-tetradecanoylphorbol-13-acetate-exposed R6 fibroblasts: minor role of protein kinase C beta I and mu.
Carcinogenesis 22(2) , 221-31, (2001) 12-O:-tetradecanoylphorbol-13-acetate (TPA) inhibits gap junctional communication in many cell culture systems, but TPA-induced phosphorylation of the gap junction protein connexin43 (Cx43) varies much between systems. We have here studied whether these respo... |
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Protein kinase C modulates insulin action in human skeletal muscle.
Am. J. Physiol. Endocrinol. Metab. 278(3) , E553-62, (2000) There is good evidence from cell lines and rodents that elevated protein kinase C (PKC) overexpression/activity causes insulin resistance. Therefore, the present study determined the effects of PKC activation/inhibition on insulin-mediated glucose transport i... |
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Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.
J. Cereb. Blood Flow Metab. 30(9) , 1593-7, (2010) Blood-brain barrier (BBB) P-glycoprotein activity is rapidly reduced by vascular endothelial growth factor (VEGF) acting via Src and by tumor necrosis factor-alpha acting via protein kinase C (PKC)beta1. To probe underlying mechanism(s), we developed an in vi... |
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Inhibition of erythema induced by pro-inflammatory esters of 12-deoxyphorbol.
Acta Pharmacol. Toxicol. (Copenh.) 48(1) , 47-52, (1981) The pro-inflammatory tigliane esters 12-deoxyphorbolphenylacetate (12-DOPPA) and 12-deoxyphorbolphenylacetate-20-acetate (12-DOPPAA) at a dose of 0.1 microgram induced erythema in the mouse ear. Observations of ear redness were made both two and four hours af... |
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Protein kinase Cdelta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs.
J. Biol. Chem. 273(51) , 34639-45, (1998) Bacterial lipopolysaccharide can induce manganese superoxide dismutase (MnSOD) gene expression in a variety of cells. Paclitaxel (taxol) shares many properties of lipopolysaccharide. Here we report that paclitaxel can induce MnSOD gene expression in human lun... |
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Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Int. J. Cancer 71(4) , 691-7, (1997) In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells, including HL60 promyelocytic leukemia cells. The present study describes the effects of activators of protein kinase C (PKC) on GGO-induced apo... |
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12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-beta isozyme-selective in vivo.
Carcinogenesis 15(2) , 319-24, (1994) The phorbol ester, 12-deoxyphorbol-13-O-phenylacetate-20-acetate (DOPPA) has been shown to activate specifically the protein kinase C (PKC)-beta 1 isozyme in vitro (1). We have investigated the potential of DOPPA as a PKC-beta 1/2 isozyme-specific agonist in ... |
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Doppa induces cell death but not differentiation of U937 cells: evidence for the involvement of PKC-beta 1 in the regulation of apoptosis.
Leuk. Res. 20(4) , 319-26, (1996) Recent reports have claimed that activation of protein kinase C (PKC)-beta is sufficient for both differentiation and apoptosis in promyeloid HL60 cells. Phorbol esters which differentially activate PKC isoenzymes in vitro were used to induce differentiation ... |
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Phorbol esters affect skeletal muscle glucose transport in a fiber type-specific manner.
Am. J. Physiol. Endocrinol. Metab. 287(2) , E305-9, (2004) Recent evidence has shown that activation of lipid-sensitive protein kinase C (PKC) isoforms leads to skeletal muscle insulin resistance. However, earlier studies demonstrated that phorbol esters increase glucose transport in skeletal muscle. The purpose of t... |
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SM22alpha is required for agonist-induced regulation of contractility: evidence from SM22alpha knockout mice.
Mol. Cells 23(2) , 175-81, (2007) The present study was undertaken to determine whether SM22alpha participates in the regulation of vascular smooth muscle contractility using SM22alpha knockout mice and, if so, to investigate the mechanisms involved. Aortic ring preparations were mounted and ... |