(2H5)Acetamide

Modify Date: 2024-01-13 18:02:50

(2H5)Acetamide Structure
(2H5)Acetamide structure
Common Name (2H5)Acetamide
CAS Number 33675-83-1 Molecular Weight 64.098
Density 0.9±0.1 g/cm3 Boiling Point 221.1±0.0 °C at 760 mmHg
Molecular Formula C2D5NO Melting Point 78-80ºC(lit.)
MSDS Chinese USA Flash Point 90.1±18.4 °C

 Use of (2H5)Acetamide


Acetamide-d5 is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].

 Names

Name N,N,2,2,2-pentadeuterioacetamide
Synonym More Synonyms

 (2H5)Acetamide Biological Activity

Description Acetamide-d5 is the deuterium labeled Acetamide[1]. Acetamide is used as an intermediate in the synthesis of methylamine, thioacetamide, and insecticides, and as a plasticizer in leather, cloth and coatings. Acetamide has carcinogenicity[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Acetamide. IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 3:1211-21.  

[3]. Moore MM, et, al. The food contaminant acetamide is not an in vivo clastogen, aneugen, or mutagen in rodent hematopoietic tissue. Regul Toxicol Pharmacol. 2019 Nov108:104451.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 221.1±0.0 °C at 760 mmHg
Melting Point 78-80ºC(lit.)
Molecular Formula C2D5NO
Molecular Weight 64.098
Flash Point 90.1±18.4 °C
Exact Mass 64.068497
PSA 43.09000
LogP -1.23
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.393

 Safety Information

Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases 36/37
RIDADR UN 3077 9 / PGIII

 Synonyms

Acetamide-d
(H)Acetamide
Acetamide-d5