25,26-Dihydroxyvitamin D3
Modify Date: 2024-01-03 09:39:53
25,26-Dihydroxyvitamin D3 structure
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Common Name | 25,26-Dihydroxyvitamin D3 | ||
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| CAS Number | 29261-12-9 | Molecular Weight | 416.63600 | |
| Density | 1.06g/cm3 | Boiling Point | 575.3ºC at 760mmHg | |
| Molecular Formula | C27H44O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 243.7ºC | |
Use of 25,26-Dihydroxyvitamin D325,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.IC50 value:Target: VD metaboliteThe biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3. |
| Name | 25,26-Dihydroxy Vitamin D3 |
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| Synonym | More Synonyms |
| Description | 25,26-Dihydroxyvitamin D3(25,26-dihydroxycholecalciferol) is a metabolite of vitamin D3 with intestinal calcium transport activity.IC50 value:Target: VD metaboliteThe biological activity of synthetic 24,25 and 25,26 diOHD3 was studied in vitamin D-deficient rats. The purpose of this study was to investigate the influence of small doses of both metabolites (0.125-0.250 mug) upon intestinal calcium transport and bone calcium mobilization. Both metabolites were able to increase calcium absorption in rats maintained on a calcium-deficient diet, but failed to do it in rats on a normal calcium diet. Bilateral nephrectomy suppressed this effect. The "bone calcium mobilization" of both derivatives was measured in vitamin D and calcium- or phosphorus-deprived rats after one intravenous dose. When serum calcium was initially low, 24,25 and 25,26 diOHD3 increased serum calcium moderately, but the increment was only significant with 24,25 diOHD3. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
| Density | 1.06g/cm3 |
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| Boiling Point | 575.3ºC at 760mmHg |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.63600 |
| Flash Point | 243.7ºC |
| Exact Mass | 416.32900 |
| PSA | 60.69000 |
| LogP | 5.70630 |
| Vapour Pressure | 1.24E-15mmHg at 25°C |
| Index of Refraction | 1.548 |
| Storage condition | 2-8℃ |
| Hazard Codes | T: Toxic; |
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| Risk Phrases | 23/24/25-63 |
| Safety Phrases | 36/37-45 |
| RIDADR | UN2811 6.1/PG 2 |
| (5E,7E)-9,10-Secocholesta-5,7,10-triene-3,25,26-triol |
| 25,26-Dihydroxyvitamin D3 |