(-)-Epigallocatechin(EGC)

Modify Date: 2024-01-02 10:08:07

(-)-Epigallocatechin(EGC) structure	Common Name	(-)-Epigallocatechin(EGC)
	CAS Number	970-74-1	Molecular Weight	306.267
	Density	1.7±0.1 g/cm3	Boiling Point	685.6±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₄O₇	Melting Point	208-210°C
	MSDS	Chinese USA	Flash Point	368.5±31.5 °C

Use of (-)-Epigallocatechin(EGC)

(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.IC50 value:Target: in vitro: EGCG is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that EGCG prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. EGCG exhibited a MIC and MBC of 5μg/mL and 20μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, EGCG induced significant down-regulation of E. faecalis virulence genes [3].

Name	(-)-epigallocatechin
Synonym	More Synonyms

Description	(-)-Epigallocatechin is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.IC50 value:Target: in vitro: EGCG is a potent inhibitor of amyloidogenic cystatin I66Q amyloid fibril formation in vitro. Computational analysis suggests that EGCG prevents amyloidogenic cystatin fibril formation by stabilizing the molecule in its native-like state as opposed to redirecting aggregation to disordered, amorphous aggregates [1]. Combined curcumin and EGCG treatment reduced the cancer stem-like Cluster of differentiation 44 (CD44)-positive cell population. Western blot and immunoprecipitation analyses revealed that curcumin and EGCG specifically inhibited STAT3 phosphorylation and STAT3-NFkB interaction was retained [2]. EGCG exhibited a MIC and MBC of 5μg/mL and 20μg/mL respectively and effectively eradicated E. faecalis biofilms. EGCG induced the formation of hydroxyl radicals in E. faecalis. The addition of DIP protected E. faecalis against EGCG-mediated antibacterial effects. At sub-MIC, EGCG induced significant down-regulation of E. faecalis virulence genes [3].
Related Catalog	Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Wang N, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26 [2]. Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46. [3]. Lee P, et al. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015 Mar;60(3):393-9.

Description

Related Catalog

Natural Products >> Flavonoids

Research Areas >> Others

References

[1]. Wang N, et al. (-)-Epigallocatechin-3-gallate Inhibits Fibrillogenesis of Chicken Cystatin. J Agric Food Chem. 2015 Jan 26

[2]. Chung SS, et al. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Anticancer Res. 2015 Jan;35(1):39-46.

[3]. Lee P, et al. Effects of Epigallocatechin gallate against Enterococcus faecalis biofilm and virulence. Arch Oral Biol. 2015 Mar;60(3):393-9.

Density	1.7±0.1 g/cm3
Boiling Point	685.6±55.0 °C at 760 mmHg
Melting Point	208-210°C
Molecular Formula	C₁₅H₁₄O₇
Molecular Weight	306.267
Flash Point	368.5±31.5 °C
Exact Mass	306.073944
PSA	130.61000
LogP	-0.10
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.776

(-)-Epigallocatechin(EGC) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KB5100000

CHEMICAL NAME :: Epigallocatechol

CAS REGISTRY NUMBER :: 970-74-1

LAST UPDATED :: 198912

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H14-O7

MOLECULAR WEIGHT :: 306.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 25 mg/L

REFERENCE :: PYTCAS Phytochemistry. An International Journal of Plant Biochemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1961- Volume(issue)/page/year: 27,1017,1988

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KB5100000
HS Code	2932999099

Precursor 4
CAS#:332386-74-0 (-)-(2R,3R)-cis... CAS#:1449477-27-3 5-((S)-hydroxy(... CAS#:1333874-50-2 alhacin CAS#:108-98-5 Thiophenol
DownStream 10
CAS#:1707-75-1 1,1-DIPHENYL-2-... CAS#:979-92-0 SAH CAS#:28543-07-9 Theaflavin-3'-g... CAS#:102208-16-2 epitheaflagallin
CAS#:569-77-7 PURPUROGALLIN CAS#:31129-95-0 Benzenepentanoi... CAS#:74356-41-5 3,5-DIHYDROXY-B... CAS#:1204316-08-4 5-(3,5-dihydrox...
CAS#:4670-05-7 Theaflavin CAS#:302776-47-2 theanaphthoquinone

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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epi

BioBioPha
China
Product Name: (-)-Epigallocatechin(EGC)
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (-)-Epigallocatechin(EGC)
Price: ￥658.0/1g ￥228.0/250mg ￥238.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (-)-Epigallocatechin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (-)-Epigallocatechin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (-)-epigallocatechin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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(-)-Epigallocatechin(EGC)

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