Eflornithine (hydrochloride, hydrate)

Modify Date: 2024-01-03 16:51:52

Eflornithine (hydrochloride, hydrate) structure	Common Name	Eflornithine (hydrochloride, hydrate)
	CAS Number	96020-91-6	Molecular Weight	236.64500
	Density	1.293g/cm3	Boiling Point	347ºC at 760mmHg
	Molecular Formula	C₆H₁₅ClF₂N₂O₃	Melting Point	>210ºC (dec.)
	MSDS	N/A	Flash Point	163.7ºC

Use of Eflornithine (hydrochloride, hydrate)

Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

Name	DL-α-Difluoromethylornithine Hydrochloride Monohydrate
Synonym	More Synonyms

Description	Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
In Vivo	Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].
Animal Admin	Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (-50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].
References	[1]. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

Density	1.293g/cm3
Boiling Point	347ºC at 760mmHg
Melting Point	>210ºC (dec.)
Molecular Formula	C₆H₁₅ClF₂N₂O₃
Molecular Weight	236.64500
Flash Point	163.7ºC
Exact Mass	236.07400
PSA	98.57000
LogP	1.91080
Storage condition	2~8°C

Eflornithine (hydrochloride, hydrate) MSDS(Chinese)

HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%