2,5-Dimethylphenol

Modify Date: 2024-01-02 06:50:25

2,5-Dimethylphenol Structure
2,5-Dimethylphenol structure
Common Name 2,5-Dimethylphenol
CAS Number 95-87-4 Molecular Weight 122.164
Density 1.0±0.1 g/cm3 Boiling Point 211.1±0.0 °C at 760 mmHg
Molecular Formula C8H10O Melting Point 75-77 °C
MSDS Chinese USA Flash Point 86.7±7.2 °C
Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger

 Names

Name 2,5-Dimethylphenol
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 211.1±0.0 °C at 760 mmHg
Melting Point 75-77 °C
Molecular Formula C8H10O
Molecular Weight 122.164
Flash Point 86.7±7.2 °C
Exact Mass 122.073166
PSA 20.23000
LogP 2.40
Vapour Pressure 0.1±0.4 mmHg at 25°C
Index of Refraction 1.540
Water Solubility 1 g/100 mL (60 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZE5775000
CHEMICAL NAME :
2,5-Xylenol
CAS REGISTRY NUMBER :
95-87-4
BEILSTEIN REFERENCE NO. :
1099260
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C8-H10-O
MOLECULAR WEIGHT :
122.18
WISWESSER LINE NOTATION :
QR B1 E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
444 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPPAF Gigiena Truda i Professional'naya Patologiya v Estonskoi SSR. Labor Hygiene and Occupational Pathology in the Estonian SSR. (Institut Eksperimental'noi i Klinicheskoi Meditsiny Ministerstva Zdravookhraneniya Estonskoi SSR, Tallinn, USSR) V.8- 1972- Volume(issue)/page/year: 8,145,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
730 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 53,227,1935
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
383 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(7-9),329,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
938 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 33(7-9),329,1968 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4000 mg/kg/20W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,413,1959

 Safety Information

Symbol GHS05 GHS06 GHS09
GHS05, GHS06, GHS09
Signal Word Danger
Hazard Statements H301-H311-H314-H411
Precautionary Statements P273-P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases R24/25;R34;R51/53
Safety Phrases S26-S36/37/39-S45-S61
RIDADR UN 2261 6.1/PG 2
WGK Germany 3
RTECS ZE5775000
Packaging Group II
Hazard Class 6.1
HS Code 2907199090

 Synthetic Route

 Customs

HS Code 2907199090
Summary 2907199090 other monophenols VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

 Articles10

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Eur. J. Med. Chem. 46 , 1512-23, (2011)

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Effect of p-xylene metabolites, p-methylbenzyl alcohol and 2,5-dimethylphenol, on rat hepatic and pulmonary microsomal metabolism.

Res. Commun. Chem. Pathol. Pharmacol. 76(1) , 117-20, (1992)

Pulmonary metabolites of p-xylene, p-methylbenzyl alcohol (PMBA) and 2,5-dimethylphenol (DMP), were employed to investigate the divergent effects of p-xylene on pulmonary and hepatic metabolism. Rats ...

 Synonyms

2,5-Dimethyl-Phenol
2, 5-Dimethylphenol
EINECS 202-461-5
2,4-DIMORPHOLINO-6-(2-THIENYL)OXADIAZINIUM TETRACHLOROFERRATE
2,5-dimethyl-phenethylamin
2,5-DIMETHYL PHENOL OR 2,5-XYLENOL
2,5-DIMETHYL PHENOL
2,5-Dimethyl-phenaethylamin
2,5-DIMETHYLPHENOL FOR SYNTHESIS
2,5-dimethyl-phenethylamine
Phenol, 2,5-dimethyl-
RARECHEM AL BW 0330
2,5-Dimethylbenzolol
2,5-DiMethylphenethylaMine 1GR
2,5-XYLENOL (OH=1)
2,5-xylenol
2,5-DIMETHYLPHENOL/2,5-XYLENOL
3,6-dimethylphenol
2.5-DIMETHYL PHENOL
2,5-Dimethylphenol
2,5-DIMETHYPHENOL
p-cumyl phenol
Entacapone
2,5-Dimethylbenzeneethanamine
MFCD00002237
2,5-DIMETHYLPHENOL (2,5-XYLENOL)
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