ML 365
Modify Date: 2024-01-04 17:31:04
ML 365 structure
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Common Name | ML 365 | ||
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| CAS Number | 947914-18-3 | Molecular Weight | 360.40600 | |
| Density | 1.253±0.06 g/cm3 (20 °C, 760 mmHg) | Boiling Point | 429.9±40.0 °C (760 mmHg) | |
| Molecular Formula | C22H20N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 365ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).IC50 value: 4 nM/16 nM(thallium influx fluorescent assay/automated electrophysiology assay) [1]Target: KCNK3 blockerML365 possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention. |
| Name | Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl] |
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| Synonym | More Synonyms |
| Description | ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3) with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay).IC50 value: 4 nM/16 nM(thallium influx fluorescent assay/automated electrophysiology assay) [1]Target: KCNK3 blockerML365 possesses more than 60-fold selectivity for inhibition of TASK1 over a closely-related, two-pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). Based on these criteria, ML365 is a best-in-class probe and is a useful pharmacological probe for in vitro studies of TASK1 function and in further studies aimed at developing therapeutic intervention. |
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| Related Catalog | |
| References |
| Density | 1.253±0.06 g/cm3 (20 °C, 760 mmHg) |
|---|---|
| Boiling Point | 429.9±40.0 °C (760 mmHg) |
| Molecular Formula | C22H20N2O3 |
| Molecular Weight | 360.40600 |
| Exact Mass | 360.14700 |
| PSA | 67.43000 |
| LogP | 4.65420 |
| Storage condition | 2-8℃ |
| ML365 |