Lagociclovir

Modify Date: 2024-01-10 10:22:10

Lagociclovir structure	Common Name	Lagociclovir
	CAS Number	92562-88-4	Molecular Weight	269.232
	Density	2.0±0.1 g/cm3	Boiling Point	633.5±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₂FN₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	336.9±34.3 °C

Use of Lagociclovir

Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value:Target: Anti-HBV compoundOral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA.

Name	2-amino-9-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
Synonym	More Synonyms

Description	Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value:Target: Anti-HBV compoundOral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA.
Related Catalog	Signaling Pathways >> Anti-infection >> HBV Research Areas >> Infection
References	[1]. Michalak TI, et al. Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B. Antimicrob Agents Chemother. 2009 Sep;53(9):3803-14.

Density	2.0±0.1 g/cm3
Boiling Point	633.5±65.0 °C at 760 mmHg
Molecular Formula	C₁₀H₁₂FN₅O₃
Molecular Weight	269.232
Flash Point	336.9±34.3 °C
Exact Mass	269.092407
PSA	119.05000
LogP	-0.53
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.834

Precursor 6
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CAS#:37070-11-4 8,2'-anhydro-8-... CAS#:118-00-3 Guanosine
DownStream 0