Motapizone
Modify Date: 2024-01-06 15:35:10
Motapizone structure
|
Common Name | Motapizone | ||
|---|---|---|---|---|
| CAS Number | 90697-57-7 | Molecular Weight | 260.31 | |
| Density | 1.47g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C12H12N4OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MotapizoneMotapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2]. |
| Name | 3-(4-imidazol-1-ylthiophen-2-yl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one |
|---|---|
| Synonym | More Synonyms |
| Description | Motapizone (NAT 05-239) is a selective PDE3 inhibitor. Motapizone moderately inhibits cytokine release in lipopolysaccharide (LPS)-induced alveolar macrophages. Motapizone also inhibits human platelet aggregation by increasing intracellular cAMP[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PDE3 |
| In Vitro | Motapizone (10 μM; 加氧化剂前 15 min) 在氧化应激条件下，对脂多糖 (LPS) 诱导的肺泡巨噬细胞的细胞因子释放有 20% 的抑制率，不过，这种抑制作用不受氧化应激影响[1]。 |
| References |
| Density | 1.47g/cm3 |
|---|---|
| Molecular Formula | C12H12N4OS |
| Molecular Weight | 260.31 |
| Exact Mass | 260.07300 |
| PSA | 87.52000 |
| LogP | 1.55830 |
| Index of Refraction | 1.75 |
| Motapizone |
| UNII-C4A61P8A37 |
| Motapizonum |
| Motapizona |
| Motapizon |